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David Waugh
David S. Waugh, a Senior Investigator at the National Cancer Institute
Dr. Waugh graduated from Yale University in 1982 with a B.S. in Molecular Biophysics & Biochemistry. He received his Ph.D. in Biochemistry & Molecular Biology from Indiana University in 1989, under the direction of Dr. Norman Pace. His doctoral dissertation, entitled "Mutational Analysis of Catalytic Function in Ribonuclease P RNA", earned him the Esther L. Kinlsey award for the outstanding Ph.D. dissertation presented to the Graduate School at Indiana University in 1989. During 1990 and 1991 he was a postdoctoral fellow in Dr. Robert Sauer's laboratory at the Massachusetts Institute of Technology, where he studied structure-function relationships in the type IIS restriction endonuclease FokI. In 1991, Dr. Waugh joined the Biomolecular Structure Group at Hoffmann-La Roche, as head of the Macromolecular Engineering Laboratory. He became a principal investigator at the National Cancer Institute in 1996 and gained tenure as a Senior Investigator in 2005. Dr. Waugh currently heads the Protein Engineering Section in the Macromolecular Crystallography Laboratory at the NCI. His research interests revolve around methods development for high-throughput protein expression and purification and X-ray crystallographic studies of virulence factors from potential agents of bioterrorism, especially Yersinia pestis. He was the recipient of Federal Technology Transfer awards in 2005-2011. Dr. Waugh is a member of the structural genomics section of the Faculty of 1000 literature awareness service and currently serves on the editorial board for the journal Protein Expression and Purification.
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